US Health Secretary Kathleen Sebelius is resigning following the problematic launch of President Barack Obama’s healthcare law, US media report.
The law – regarded by the president’s supporters as one of his main domestic achievements – has been marked by early technical problems and delays.
Ms Sebelius has been health secretary since Mr Obama took office in 2009.
The reports say Mr Obama will nominate Sylvia Mathews Burwell, the current budget director, to replace her.
Ms Sebelius had made the decision to resign herself, the New York Times reported.
The US president had resisted calls for the health secretary to stand down after the websites where people could enrol for health insurance ran into problems last October.
